차세대 지질나노입자 기반 생체 내 유전체 편집기술 개발 과제

연구책임자 : 이화여자대학교 이혁진 교수

Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. 

However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. 

Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. 

This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. 

Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles.  

Experimental & Molecular Medicine 55, 2085-2096 (2023) 

https://www.nature.com/articles/s12276-023-01086-x